The No. 17 USC Trojans (7-2) and the Iowa Hawkeyes (6-3) play on Saturday, November 15, 2025 at Los Angeles Memorial Coliseum in a battle of Big Ten foes.
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USC vs. Iowa Matchup Info
- Game date: Saturday, November 15, 2025
- Game time: 3:30 p.m. ET
- Location: Los Angeles, California
- Venue: Los Angeles Memorial Coliseum
- TV channel: BTN
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
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USC vs. Iowa Odds and Prediction
- Spread favorite: Trojans (-6.5)
- Moneyline: Trojans (-240), Hawkeyes (+196)
- Total: 48.5 points
- Pick ATS: USC (-6.5)
- Pick OU: Over (48.5)
- Prediction: USC 30, Iowa 22
Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.
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USC vs. Iowa Betting Records and Insights
- USC has put together a 5-4-0 record against the spread this season.
- Iowa has put together a 6-2-1 ATS record so far this year.
- The Trojans have an ATS record of 3-3 when playing as at least 6.5-point favorites this season.
- The Hawkeyes have covered the spread when playing as at least 6.5-point underdogs in their only opportunity this season.
- So far this season, five of USC's nine games have hit the over.
- Iowa and its opponent have combined to go over the point total four out of nine times this season.